Document Type : Articles
Authors
1 Department of Animal Production, College of Agriculture, Tikrit University, Iraq.
2 Department of Animal Genetics, Breeding, and Reproduction, College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China
3 Biology Department, Education College for Women, University Of Anbar, Ramadi, Iraq.
4 Animal Production Research Institute, Agriculture Research Center, Dokki, 12619. Giza, Egypt.
Abstract
Selenium is a vital nutrient for poultry, crucial for immune system regulation and function. We investigated the effects of dietary selenium (Se) supplementation on the expression genes of an immune response, selenoprotein P, programmed cell death, Antioxidants, and metabolism genes in the development of chicken liver. 400 chicks (broiler) of males were used and birds were divided equally across 4 diet treatments as 100 birds for each treatment. The control first group (T1) was fed a standard diet, the second experiment group (T2) was fed the experimental diet (a basic diet containing + 0.4 mg inorganic selenium Se/kg) and nontreated water, the third experiment group (T3) added selenium to water (standard diet and treated water (300ppm) Solution selenium), and the fourth experiment group (T4) added selenium to water (Solution selenium 300ppm) and to fed the experimental diet (basic diet containing + 0.4mg inorganic selenium Se/kg). The liver was collected individually after 6 weeks of feeding. The results indicated that IL-1β gene expression increased in T4 and the SePP1 gene increased in T3, as a significant increase in the Fas and FaslG genes in T4 and T3 respectively. Antioxidants and metabolic genes also increased in the T4 and T3 respectively. Therefore, these results indicate that nutritional supplements containing selenium especially when given with water or with water and feed, improve the immune response, apoptosis, antioxidants, and metabolic genes in chicken liver tissue.
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