Document Type : Articles
Authors
1 Department of Biology, College of Education for Pure Sciences, University of Anbar
2 Anbar Health Directorate – Fallujah, Iraq
Abstract
The aim of this study was to assess the therapeutic effects of Cordia myxa (Bumber ) against cardiototoxicity caused by Isoprenaline (ISO) in male Wistar rats. Twenty eight adult Wistar male albino rats were equally divided into four groups, In Group I (control group received saline at a dose of (0.1 ml/100 g, S.C.) , Group II (MI group): Isoproterenol dissolved in sterile saline was injected subcutaneously (0.1 ml / 100 g) for 3 consecutive days at 24 h time to induce AMI. rat were killed 24 hours after the last injection, while Group III: Each rats oral dosage with C. myxa (250 mg/kg body weight) for 14 days , and Group IV (C. myxa later) ISO+ C. myxa . cardioprotective effects of Cordia myxa were manifested by decrease in the elevated serum levels activities of cardiac enzymes (CK-MB, cTnI, AST and LDH) together with the improvement of heart bio indicators of oxidative stress(MDA) and antioxidant defense system ( GSH ). Histopathological changes of heart were observed in second group (treated with ISO) and fourth group (ISO + Cordia myxa treated) as compared to control group. This study demonstrated the antioxidant effect of Cordia myxa and against ISO -induced cardiac injury.
Keywords
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