Document Type : Articles
Author
AL-DourTechnical Institute, Northern Technical University, Iraq
Abstract
The study investigated the effects of gold nanoparticles and the drug Domperidone on the reproductive system of local female rabbits. Female rabbits weighing between 1500-1700 grams were divided into four groups, with five rabbits in each group. The first group (control) received only water and food, while the second group was given Domperidone orally at a dose of 0.3 mg/kg three times daily with water and food. The third group received a gold nanoparticle solution at a dose of 0.05 mg/kg, with a concentration of 3.271 mg * 10^-7 and a gold particle diameter of 60 nm, administered once daily for two days per week. The fourth group received both Domperidone at 0.3 mg/kg and the gold nanoparticle solution at 0.05 mg/kg, following the same dosing schedule. All treatments lasted for 50 days. The results showed that the combination of gold nanoparticles and Domperidone led to a decrease in LH hormone levels compared to the control group. Additionally, the group receiving both the drug and nanoparticles exhibited a further reduction in LH levels. A significant histological finding was the lysis of primary follicles in the ovaries of rabbits in the Domperidone group. These observations suggest that both the drug and nanoparticles may have notable effects on the reproductive physiology of female rabbits.
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