Document Type : Articles
Authors
1 Department of basic science/College of Dentistry/Al-Iraqia University
2 Department of Physiology,Biochemistry and Pharmacology, College of veterinary medicine, University of Mosul, Mosul, Iraq.
Abstract
Boswellia serrata (B.serrata) is commonly defined as a resin, widely used because of the healing properties of inflammations and other diseases due to its powerful antioxidant action. This study investigates the effect of B.serrata on reproductive system and metabolic hormones in adult male rats. Four groups of adult male rats (10 rats each) were subjected to the trail. Group 1 (control ) rats were fed on normal diet (ND), group (2) rats were fed on high fat diet (HFD), group (3) rats were fed ND and aqueous B.serrata extract (1000 mg/kg body weight/day), and group (4) rats fed on HFD and aqueous B.serrata extract at the same dose respectively for the duration of 60 days. The results indicated that feeding on HFD resulted in hyperlipidemia, significant (p≤0.05) reduced level of testosterone, insulin, TSH and the antioxidant enzymes (GSH, SOD,CAT), significant (p≤0.05) elevated levels of lipid profile, oxidative markers (MDA) and cytokines (TNF-α, IL-6 and IL-1β) concentration. Negative effects on spermatogenesis was also observed, confirmed by significant (p≤0.05) decrease in sperm concentration and sperm motility in addition to significant (p≤0.05) increase in the percentage of dead and abnormal sperm. Daily aqueous B.serrata extract administration for 60 days managed to adjust all the metabolic disorders and enhanced rats fertility. The study concluded that the administration of B.serrata extract improves the adverse effects of high fat diet by acting as antidyslipidemic, anti-inflammatory and antioxidant agent. B. serrata extract is also able to correct the disrupted metabolic pathways, with positive effect on male fertility.
Keywords
)