Document Type : Articles
Author
Department of Biology, College of Pure Science, Tikrit University, Iraq
Abstract
This study aimed to elucidate the promising potential of silymarin in ameliorating the side effects associated with toxic pharmaceuticals. The study involved thirty female rats obtained, housed and maintained under requisite laboratory conditions in animal house unit in college of veterinary medicine, University of Tikrit. Rats distributed into six groups five rats per group to investigate the effects of Cisplatin and silymarin on various biochemical markers over a 21-day period. The groups included a control group, two induction groups receiving Cisplatin 5mg/kg on first and last days, a silymarin group 150mg/kg orally per day, a therapeutic group included Cisplatin 5mg/kg i.p. and silymarin 150mg/kg, and a protective group treated silymarin 150mg/kg and Cisplatin 5mg/kg administration in last day. This experimental study aimed to evaluating the effect of cisplatin and silymarin administration for 21 days on some physiological and histological parameters in rats included Alanine transaminase ALT, Aspartate aminotransferase AST, Glutathione peroxidase GPx, Glutathione GSH, Superoxide dismutase SOD, Malondialdehyde MDA levels, and histological changes in liver tissue. Results demonstrated the adverse effect of cisplatin on ALT, AST, GPx, GSH, SOD levels and liver tissue also demonstrated the protective and therapeutic potential effect of silymarin against oxidative stress and hepatotoxicity induced by cisplatin due increase GPx, GSH, SOD and decrease MDA, AST levels, also enhanced liver tissue. From the results we conclude the potential protective and therapeutic role of silymarin against hepatotoxicity and oxidative stress induced by cisplatin.
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